| Entry |
|
|---|
| Name |
Methyldopa (INN);
Aldomet (TN) |
|---|
| Formula |
C10H13NO4
|
|---|
| Exact mass |
211.0845
|
|---|
| Mol weight |
211.2145
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01738 Centrally-acting antiadrenergic
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
DG01951 Catecholamine adrenergic receptor agonist
DG01617 Catecholamine synthesis inhibitors
DG03231 Antihypertensive
|
|---|
| Remark |
| Product (DG00248): | D00405<JP/US> |
|
|---|
| Efficacy |
Antihypertensive, alpha2-Adrenergic receptor agonist |
|---|
| Comment |
Peripheral aromatic L-amino acid decarboxylase inhibitors (DCI)
Dopamine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C02 ANTIHYPERTENSIVES
C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING
C02AB Methyldopa
C02AB01 Methyldopa (levorotatory)
D08205 Methyldopa (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01738 Centrally-acting antiadrenergic
DG00248 Methyldopa (levorotatory)
D08205 Methyldopa
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
DG00248 Methyldopa (levorotatory)
D08205 Methyldopa
DG01951 Catecholamine adrenergic receptor agonist
DG00248 Methyldopa (levorotatory)
D08205 Methyldopa
DG01617 Catecholamine synthesis inhibitors
DG00248 Methyldopa (levorotatory)
D08205 Methyldopa
DG03231 Antihypertensive
DG00248 Methyldopa (levorotatory)
D08205 Methyldopa
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA2
D08205 Methyldopa (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01738 Centrally-acting antiadrenergic
DG00248 Methyldopa (levorotatory)
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
DG00248 Methyldopa (levorotatory)
DG01951 Catecholamine adrenergic receptor agonist
DG00248 Methyldopa (levorotatory)
DG01617 Catecholamine synthesis inhibitors
DG00248 Methyldopa (levorotatory)
DG03231 Antihypertensive
DG00248 Methyldopa (levorotatory)
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 15
1 C1d C 27.4400 -15.8200
2 C6a C 28.6300 -15.1200
3 C1b C 26.2500 -15.1200
4 C1a C 26.9500 -17.2200
5 N1a N 28.4200 -17.2200
6 O6a O 29.8200 -15.8200
7 O6a O 28.6300 -13.7900
8 C8y C 25.0600 -15.8200
9 C8x C 23.8700 -15.1200
10 C8x C 25.0600 -17.2200
11 C8y C 22.6800 -15.8200
12 C8x C 23.8700 -17.8500
13 C8y C 22.6800 -17.2200
14 O1a O 21.4900 -15.1200
15 O1a O 21.4900 -17.8500
BOND 15
1 1 2 1
2 1 3 1
3 1 4 1 #Down
4 1 5 1 #Up
5 2 6 1
6 2 7 2
7 3 8 1
8 8 9 1
9 8 10 2
10 9 11 2
11 10 12 1
12 11 13 1
13 11 14 1
14 13 15 1
15 12 13 2
|
|---|
